1. To provoke impatience, anger, or displeasure.
  2. To introduce irritability or irritation in.
  3. To cause or induce displeasure or irritation.
  4. To induce pain in (all or part of a body or organism).
  5. To render null and void.

The above text is a snippet from Wiktionary: irritate
and as such is available under the Creative Commons Attribution/Share-Alike License.

Need help with a clue?
Try your search in the crossword dictionary!