Potential answers for "Significant suffering"

⭐⭐⭐⭐ AGONY
⭐ EPOCHAL
⭐ ILLS
⭐ MAINSQUEEZE
⭐ COUNTED
⭐ LYINGAWAKE
⭐ BEAU
⭐ JUMBOCDS
⭐ GREATDIVIDE
⭐ LIMPBIZKIT

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Resort island east of Java   Angler's wear   Dahomey, since 1975