Potential answers for "Lost its effect"

⭐⭐⭐⭐ WOREOFF
⭐⭐ ARAL
⭐⭐ TIMELAG
⭐⭐ EDEN
⭐⭐ QUEZONCITY
⭐⭐ DRPEPPER
⭐⭐ NAUSEA
⭐⭐ PEPSI
⭐⭐ ARGONNE

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American marsupial, commonly   USNA graduate, perhaps   C.P.R. administrant