Potential answers for "It really gets under your skin"

⭐⭐⭐⭐ PETPEEVE
⭐⭐⭐ TIE
⭐⭐⭐ FLEA
⭐⭐⭐ NEEDLE
⭐⭐⭐ NETTLES
⭐⭐⭐ IRKS
⭐⭐⭐ SPLINTER
⭐⭐⭐ PEEVES
⭐⭐⭐ ANNOYS

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