Potential answers for "Having a significant effect"

⭐⭐⭐⭐ IMPACTFUL
⭐⭐⭐ IMPACT
⭐⭐⭐ SERIOUS
⭐⭐ OPERANT
⭐⭐ DETERRENCE
⭐⭐ NULL
⭐⭐ DELETERIOUS
⭐⭐ NAUSEA
⭐⭐ EFFICACIOUS
⭐⭐ TAKINGITSTOLL

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