Potential answers for "Downer drug, informally"

⭐⭐⭐⭐ TRANK
⭐⭐⭐ OPIATE
⭐⭐ SPEEDBUMP
⭐⭐ DRAG
⭐⭐ ABM
⭐⭐ ACE
⭐⭐ AXE
⭐⭐ BIGBADWOLF
⭐⭐ NOSALE

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