Potential answers for "Cause of a backup"

⭐⭐⭐⭐ CLOG
⭐⭐ THIRDSTRINGER
⭐⭐ THIRDSTR
⭐ REEK
⭐ IRS
⭐ ECOLI
⭐ ALLERGY

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It can be raw   Gained vigor (with "up")   Gaucho's rope (Var.)