Potential answers for "Anesthetic since the 1840s"

⭐⭐⭐⭐ ETHER
⭐⭐ LOCAL
⭐⭐ TYLER
⭐⭐ TYLERS
⭐⭐ FREESOILER
⭐⭐ LAUGHINGGAS
⭐⭐ TOPICAL

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__ souci (carefree)   Part of the back forty   Pulling up pots in Chesapeake Bay, say