Potential answers for "Main cause"

⭐⭐⭐⭐ KEYFACTOR
⭐ REEK
⭐ IRS
⭐ ECOLI
⭐ ALLERGY
⭐ TORT
⭐ ROOT
⭐ SMOG
⭐ TORNADO
⭐ FEAR

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Older form of a word   Juniors, e.g.   "___ off!"