Potential answers for "Downers, in brief"

⭐⭐⭐⭐ TRANKS
⭐⭐ SARALEE
⭐⭐ QUAALUDES
⭐⭐ LUDES
⭐⭐ GAINS
⭐⭐ SEDATIVES
⭐⭐ BUMMERS
⭐⭐ OPIATES
⭐ ENOTE

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